Background / Overview :
When health economic evaluations are conducted in the preparation of pricing and/or reimbursement dossiers, often indirect comparisons of treatment effects are required. Indeed, in health economic evaluations one should compare to the most likely to be replaced, but often direct comparisons are not available. In such situations an indirect comparison can be a solution. For instance, a comparison between A and C is required, but only a comparison between A and B and a comparison between B and C exist. In such a case, techniques for indirect comparison can be applied. These techniques can range from very simple to very complex. Each technique has methodological and validity issues at least to some extent. No clear guidance currently exists on what is recommended or at least what is not good practice.
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